The Therapeutic Effect of Sufficient Oxygen-Rich PRP Injection in Facial Rejuvenation by Multiple Objective Evaluations in 26 Cases

This study on 26 patients assessed the effects of oxygen-rich PRP injections for facial rejuvenation. Results showed that high-dose ozonized PRP increased growth factors like EGF and TGF-β, enhancing tissue repair and collagen thickness by up to 30% in the forehead, cheek, and neck, with effects lasting up to 6 months. Skin conditions such as spots and texture improved significantly, though wrinkles and pore size did not. Patient satisfaction was high, with 46.2% reporting significant improvement and 53.85% willing to repeat the treatment. The procedure was well-tolerated, with a median pain score of 4.19 out of 10, and minor side effects like edema and redness resolved quickly. The study suggests that oxygen-rich PRP injections, especially with ozone activation, are promising for facial rejuvenation, but further research is needed on activation methods and pain management.