Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation

April 2019 in “ Institutional Repositories DataBase (IRDB) ”

ZHENG Yunwen, Liu Li-Ping, Li Yu-Mei, Guo Ning-Ning, Li Shu, Ma Xiaolong, Zhang Yi-Xuan, Gao Yimeng, Huang Jian-Ling, Zheng Dong-Xu, Wang Lu-Yuan, Xu Hui, Hui Lijian

induced pluripotent stem cells iPSC melanocytes hiMels autologous transplantation vitiligo MITF PAX3 TYRP1 melanin hair follicles pigmented hair cellular therapy depigmentation disorders stem cells skin pigmentation hair pigmentation personalized therapy

TLDR Patient-derived stem cell melanocytes could be a promising treatment for vitiligo.

The study explored the therapeutic potential of human induced pluripotent stem cell-derived melanocytes (hiMels) for autologous transplantation in vitiligo patients. Researchers generated hiMels using a three-dimensional system that enhanced differentiation efficiency, showing characteristics similar to human epidermal melanocytes and involvement in vitiligo-associated signaling pathways. In vivo experiments demonstrated that MITF+PAX3+TYRP1+ hiMels localized in mouse hair bulbs and epidermis, producing melanin for up to 7 weeks post-transplantation. Additionally, MITF+PAX3+TYRP1- hiMelanocyte stem cells integrated into bulge-subbulge regions. These findings indicated that hiMels could reconstitute pigmented hair follicles and integrate into normal regions, offering a potential personalized cellular therapy for depigmentation disorders.

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