Phytochemical and Nanoparticle-Based Therapeutic Potential of Sphaeranthus Indicus Against Hepatocellular Carcinoma via Cryptomeridiol Targeting

    November 2025 in “ Frontiers in Oncology ”
    Ritika Ravindra Konduskar, Abhinandan Patil, Somnath D. Bhinge, Garima Chawla, Yash Bhagavan Yadav
    TLDR Sphaeranthus indicus and silver nanoparticles can help treat liver cancer by killing cancer cells.
    The study investigates the therapeutic potential of Sphaeranthus indicus (Si) extract, cryptomeridiol, and silver nanoparticles (SiAgNPs) against hepatocellular carcinoma. These agents were found to effectively induce apoptosis and inhibit the proliferation of HepG2 cells, a type of liver cancer cell, in an in-vitro model. The findings suggest that cryptomeridiol is a potent phytochemical scaffold and demonstrate the potential of combining phytochemicals with nanotechnology for developing therapies for hepatocellular carcinoma.
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