Therapeutic Potential of Secretome from Hypoxic-Mesenchymal Stem Cell (SH-MSC) in Regulating PDGF and IL-1β Gene Expression in Fluconazole-Related Alopecia

Fluconazole-related alopecia is linked to increased IL-1β and decreased PDGF. This study investigated the therapeutic potential of secretomes from hypoxic mesenchymal stem cells (SH-MSCs) in regulating these gene expressions. Using six rats per group, the study compared a positive control, a negative control with fluconazole, and two groups treated with 10% and 20% SH-MSCs. After 29 days, SH-MSCs significantly increased PDGF and decreased IL-1β expression, with the highest PDGF expression and lowest IL-1β expression in the 20% SH-MSC group. Histopathological analysis showed improved hair follicle tissue, suggesting SH-MSCs as a promising topical treatment for fluconazole-related alopecia.