Thyroid Dysfunction and Alopecia Areata: A Genetic Prediction Causality Analysis Study

September 2024 in “ Skin Research and Technology ”

Yue Zhao, Furong Guo, M. Guo

alopecia areata thyroid dysfunction hypothyroidism Hashimoto's thyroiditis subacute thyroiditis Mendelian randomization AA

TLDR The study initially suggested a genetic link between thyroid issues and hair loss.

This study, which has been retracted, initially suggested a genetic link between thyroid dysfunctions such as hypothyroidism, Hashimoto's thyroiditis, subacute thyroiditis, and alopecia areata (AA). Using the two-sample Mendelian randomization (MR) method, the study aimed to provide unbiased results confirming a causal relationship. The findings were intended to support further research into the biological mechanisms connecting thyroid dysfunction and AA, as well as potential clinical applications.

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Research cited in this study

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research Retracted: Genetic Association Between Asthma and Alopecia Areata: A Two-Sample Mendelian Randomization Study

3 citations , July 2024 in “Skin Research and Technology”

Asthma may increase the risk of alopecia areata.

research Retracted: Causal Role of Immune Cells in Alopecia Areata: A Two-Sample Mendelian Randomization Study

14 citations , January 2024 in “Skin Research and Technology”

The study suggested certain immune cells might cause alopecia areata, but it was retracted.

Physician and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries

research Physician and Patient-Reported Severity and Quality of Life Impact of Alopecia Areata: Results from a Real-World Survey in Five European Countries

2 citations , October 2023 in “Dermatology and therapy”

Alopecia areata severely impacts quality of life, causing anxiety, depression, and work impairment.

research Impact of Thyroid Dysfunction on Hair Disorders

August 2023 in “Cureus”

Thyroid problems can cause hair loss and change hair texture.

research Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

3 citations , July 2023 in “International journal of molecular sciences”

Stress may contribute to hair loss in alopecia areata by affecting immune responses and cell death in hair follicles.

research Trends in Prevalence and Incidence of Alopecia Areata, Alopecia Totalis, and Alopecia Universalis Among Adults and Children in a US Employer-Sponsored Insured Population

75 citations , March 2023 in “JAMA Dermatology”

Alopecia areata and its severe forms are becoming more common, especially among females, adults, and people in the Northeast.

research Alopecia Areata: Burden of Disease, Approach to Treatment, and Current Unmet Needs

1 citations , March 2023 in “Clinical, Cosmetic and Investigational Dermatology”

Current treatments for Alopecia Areata have mixed success, and there's a need for better, more accessible options and support for affected individuals.

research An Update on Alopecia and Its Association With Thyroid Autoimmune Diseases

January 2023 in “European endocrinology”

People with alopecia have a higher risk of thyroid cancer.

Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

research Alopecia Areata: Overview and Insights from January 2018

290 citations , December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum

22 citations , June 2013 in “Australasian Journal of Dermatology”

Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.

research Genetic Basis of Alopecia Areata

40 citations , October 2012 in “Dermatologic clinics”

More research is needed to understand the genetic causes of Alopecia areata to develop better treatments.

research Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases

109 citations , May 2011 in “Dermatologic Therapy”

Alopecia areata is a type of hair loss that can lead to complete baldness, often associated with other autoimmune conditions, and half of the cases may see hair return within a year.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.