Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway

    June 2022 in “ Stem Cell Research & Therapy ”
    Jiachen Sun, Hongqing Zhao, Chuanan Shen, Shiyi Li, Wen Zhang, Jinglong Ma, Zhisheng Li, Ming Zhang, Jianqiu Yang
    TLDR Tideglusib helps heal wounds in older skin.
    The study investigated the effects of Tideglusib on wound healing in aged skin by activating the PI3K/Akt pathway, which declined with age. Conducted on 225 rats of varying ages, the research showed that Tideglusib improved wound healing, particularly in older rats, by enhancing PI3K/Akt phosphorylation and overcoming the limitations of EGF due to reduced EGFR expression in aged skin. The findings suggested that Tideglusib, especially when combined with EGF, could be a promising therapeutic agent for enhancing wound healing in the elderly. However, the study noted limitations, such as reliance on animal data and the exclusive use of male specimens, indicating a need for further research.
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