Tissue Engineering: Strategies, Tissues, And Biomaterials
July 2017
in “
Biotechnology and Genetic Engineering Reviews
”
tissue engineering scaffold-based approaches scaffold-free approaches growth factors stem cells skin engineering cartilage engineering in vivo viability vascularization endothelial cells perfusion bioreactors cell sources cell modification techniques supportive matrices natural scaffolds synthetic scaffolds
TLDR Tissue engineering needs the right mix of cells, scaffolds, and techniques to work well.
The document reviewed tissue engineering strategies as of 2017, focusing on scaffold-based and scaffold-free approaches, the use of growth factors, stem cells, and computational modeling. It highlighted successes in engineering tissues like skin and cartilage for clinical use, but noted challenges such as in vivo viability, functionality, and vascularization, which limited broader applications. Strategies to improve vascularization included endothelial cells and perfusion bioreactors. The review emphasized the importance of selecting appropriate cell sources, cell modification techniques, and supportive matrices, with various natural and synthetic scaffolds explored for different tissues. Despite promising results, a deeper understanding of cell, inducer, and scaffold interactions was needed to overcome existing challenges in tissue engineering.
