Profile of Tofacitinib Citrate and Its Potential in the Treatment of Moderate-to-Severe Chronic Plaque Psoriasis

    January 2016 in “ Drug design, development and therapy ”
    Vito Di Lernia, Federico Bardazzi
    Image of study
    TLDR Tofacitinib citrate is effective for moderate-to-severe chronic plaque psoriasis but has safety concerns at higher doses.
    Tofacitinib citrate, an oral JAK inhibitor, showed promise in treating moderate-to-severe chronic plaque psoriasis by interrupting intracellular signaling and suppressing immune cell activation. Clinical trials demonstrated that a 10 mg bid dose of tofacitinib was as effective as etanercept 50 mg administered subcutaneously twice weekly. However, safety concerns remained for doses beyond 5 mg bid. The review also suggested potential future applications of tofacitinib in treating other skin diseases, such as alopecia areata and vitiligo.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 12 results

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 10 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  2 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community can someone help me identify these pls

      in Treatment 3 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       7 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

    Similar Research

    5 / 895 results