Topical Glutamic Acid as a Regenerative Strategy in Post-Burn Alopecia: Review of Evidence and Clinical Perspectives

This review examines the potential of topical glutamic acid as a regenerative treatment for post-burn alopecia, particularly in cases of deep partial-thickness injuries. Preclinical evidence from murine models shows that glutamic acid promotes keratinocyte proliferation, inhibits apoptosis, induces angiogenesis, and activates key signaling pathways, resulting in accelerated hair growth and increased dermal vascularization after 14 days of treatment. The study highlights the promising nature of glutamic acid as a low-cost and easily applicable treatment for stimulating follicular regeneration, though further controlled clinical studies are necessary to confirm its efficacy and safety in human subjects.