Topical Therapy and Skin Care for Transplant-Associated Atopic Dermatitis in Children and Adolescents

This case report discusses five children and adolescents who developed new-onset atopic dermatitis following allogeneic hematopoietic stem cell transplantation. The study highlights that these patients, who all received systemic tacrolimus as graft-versus-host disease prophylaxis, achieved complete donor chimerism and experienced acute graft-versus-host disease of the skin. Despite this, none met the criteria for chronic graft-versus-host disease. The application of topical therapy and skin care, guided by atopic dermatitis guidelines, led to improvements in skin condition and severity scores, as well as a reduction in type 2 inflammatory markers. The findings suggest that such topical treatments can be effective for managing transplant-related atopic dermatitis, potentially reducing the need for excessive immunosuppressive therapy when the condition aligns with atopic dermatitis diagnostic criteria.