Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice

    January 2026 in “ MDPI (MDPI AG) ”
    Byeongyong Ahn, Hojun Choi, Joori Yum, Dayoung Kim, Xue Li, Chankyu Park
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    TLDR The hairy ear mutation in mice is linked to changes in gene expression affecting hair growth.
    The study investigates the molecular basis of the hairy ear (Eh) mutation in heterozygous mice, which results in elongated and additional ear hairs. RNA-seq analysis of ear tissues from four-week-old Eh/+ and wild-type mice identified 2092 differentially expressed genes, with significant alterations in hair growth-related processes. Notably, hair keratin and keratin-associated protein genes were upregulated in Eh/+ mice, while epithelial keratin genes were downregulated. Genes associated with hair follicle growth, such as Car6 and Gprc5d, showed increased expression. These findings suggest that the disruption of the Hoxc gene cluster influences the expression of hair keratin and Krtap genes, providing insights into the regulatory mechanisms of the hairy ear phenotype.
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