Comparative Transcriptome Profiling Provides New Insights Into Mechanisms of Androgenetic Alopecia Progression

May 2016 in “ British Journal of Dermatology ”

Elaine G.Y. Chew, B.S.‐Y. Ho, S. Ramasamy, Todd E. Dawson, Chandana Tennakoon, Xia-Ji Liu, W.M.S. Leong, S.Y.S. Yang, S.Y.D. Lim, H. Jaffar, Axel M. Hillmer, Mei Bigliardi-Qi, Paul L. Bigliardi

androgenetic alopecia hair follicles lipid synthesis electron transport miniaturization of hair follicles AGA

TLDR AGA progression involves increased lipid synthesis, electron transport, and hair follicle miniaturization.

This study analyzed the transcriptome of hair follicles in patients with androgenetic alopecia (AGA) and compared them to controls. The results showed that lipid synthesis and electron transport related genes were up-regulated in AGA patients compared to controls. Additionally, miniaturization of hair follicles was observed in AGA patients. The study provides new insights into the mechanisms of AGA progression.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

Oxidative stress affects hair loss in men with androgenetic alopecia.

research Low-Level Laser Therapy for Treatment of Hair Loss

165 citations , August 2013 in “Lasers in Surgery and Medicine”

Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.

research S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents

151 citations , August 2010 in “British Journal of Dermatology”

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

Related Community Posts Join

6 / 1000+ results

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

in Research/Science 486 upvotes 1 year ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

in Finasteride/Dutasteride 2 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 40 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 75 upvotes 1 year ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Interesting article links major MPB theories to western diet (and life-style)

in Research/Science 58 upvotes 1 year ago

Poor diet and lifestyle contribute to male pattern baldness. Treatments like Minoxidil, dietary changes, and lifestyle adjustments may help slow hair loss.

Similar Research

6 / 1000+ results

Formulation Development and Investigations on Therapeutic Potential of Nanogel from Beta Vulgaris L. Extract in Testosterone-Induced Alopecia

research Formulation Development and Investigations on Therapeutic Potential of Nanogel from Beta Vulgaris L. Extract in Testosterone-Induced Alopecia

2 citations , January 2023 in “BioMed Research International”

Beetroot extract nanogel may help treat hair loss caused by testosterone.

The Biology and Genomics of Human Hair Follicles: A Focus on Androgenetic Alopecia

research Novel Iron Oxide Nanocarriers Loading Finasteride or Dutasteride: Enhanced Skin Penetration for Topical Treatment of Alopecia

12 citations , July 2020 in “International Journal of Pharmaceutics”

Iron oxide nanoparticles improve skin penetration and drug release for hair loss treatment.

research Biology of Human Hair: Know Your Hair to Control It

13 citations , January 2010 in “Advances in Biochemical Engineering / Biotechnology”

Understanding hair biology is key to developing better treatments for hair and scalp issues.