TLDR Transfollicular drug delivery can improve medication absorption through hair follicles.
The document discussed the potential of hair follicles as a route for drug delivery, highlighting their complex structure and interaction with various cells and molecules. It reviewed several studies showing that transfollicular drug delivery could enhance the absorption of topical and systemic medications, including minoxidil, adapalene, and caffeine. Techniques such as using foams, microemulsions, and liposomes were found to improve drug penetration through hair follicles more effectively than traditional methods. The findings suggested that transfollicular delivery could be a promising alternative to other drug delivery methods, particularly for large or hydrophilic molecules.
35 citations
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January 2018 in “Skin pharmacology and physiology” Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.
122 citations
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March 2013 in “Expert opinion on drug delivery” Optimizing drug delivery to hair follicles is crucial for effective treatment.
74 citations
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June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics” Minoxidil foam enters hair follicles and skin for hair growth.
182 citations
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December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.
161 citations
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April 2006 in “Journal of Investigative Dermatology” Liposomes with certain properties can effectively deliver drugs deep into hair follicles.
82 citations
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January 2002 in “Journal of drug targeting” Drugs penetrate scalp skin better than abdominal skin, with scalp hair follicles aiding in higher drug delivery.
82 citations
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January 1994 in “Skin Pharmacology and Physiology” Hair follicles and glands significantly increase steroid absorption in skin.