Efficacy and Safety of Trastuzumab Deruxtecan in the Treatment of HER2-Low/Positive Advanced Breast Cancer: A Single-Arm Meta-Analysis

    June 2023 in “ Frontiers in Pharmacology ”
    Zongyu Li, Shangwen Guo, Haoyi Xue, Luying Li, Yuyuan Guo, Sinuo Duan, He Zhu
    TLDR Trastuzumab deruxtecan is effective for advanced breast cancer but has side effects like nausea and fatigue.
    This meta-analysis assessed the efficacy and safety of trastuzumab deruxtecan (DS-8201) in treating HER2-low/positive advanced breast cancer, involving 1,108 patients from 10 studies. The overall response rate (ORR) was 57%, with higher efficacy in HER2-positive patients (64% ORR) compared to those with low HER2 expression (46% ORR). The disease control rate (DCR) was 92%, with HER2-positive patients showing a higher DCR (96%) than those with low HER2 expression (87%). Common adverse events included nausea (62%), fatigue (44%), and hair loss (38%), with drug-related interstitial lung disease occurring in 10.5% of patients. Despite promising results, the study noted limitations such as small sample sizes and nonrandomized studies, highlighting the need for further research.
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