Trichothiodystrophy: An Ultrastructural Study of the Hair Follicle

The study conducted detailed ultrastructural and electron histochemical analyses on the hair shaft and anagen hair follicle in trichothiodystrophy, revealing reduced and disoriented protein deposition in the follicle, along with overall distortion in anagen follicles. Both the hair cuticle and cortex high sulfur protein components were affected. These findings provided a visual interpretation that complemented biochemical studies by other researchers, enabling specific localization of the intrinsic keratin abnormality.