TLDR Truncated hHb1 keratin may play a role in breast cancer cell transformation.
The study investigated the expression of a truncated form of hHb1 hair keratin in human breast carcinomas. It was found that breast carcinomas ectopically expressed a 5'-truncated mRNA of hHb1, which was restricted to malignant epithelial cells. The in vitro study suggested that this truncated mRNA could be translated, indicating a potential role in epithelial cell transformation. The hHb1 gene is located in a chromosome region (12q11-q13) known for breakpoints in solid tumors, suggesting it might be a target for genetic alterations in cancer.
8 citations
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April 1997 in “Experimental Dermatology” hHbl gene is active in hair shaft cells and some pilomatricomas.
61 citations
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February 1997 in “Differentiation” Hair differentiation starts earlier than thought, involving multiple type-II keratins.
52 citations
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October 1995 in “Experimental Cell Research” Human hair keratin genes hHa2 and hHb1 are located on chromosomes 17 and 12.
48 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Hair growth is controlled by specific gene clusters and proteins, and cysteine affects hair gene expression in sheep.
65 citations
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February 1992 in “Development” Type II keratin genes are crucial for hair follicle differentiation and have a conserved structure and expression pattern.
248 citations
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April 1988 in “Differentiation” Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.
