Tibial Cortex Transverse Transport Accelerates Diabetic Wound Healing Via Systemic Mobilization Of Non-Classical Monocytes

    August 2026 in “ Bone and Joint Research ”
    Yongkang Yang, Zhaowei Jiang, Kan Ouyang, Yucong Li, Jian Zhang, Haixing Wang, Shanshan Bai, Sien Lin, Xiaomin Wu, Gang Li, Xiaohua Pan
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    TLDR TTT speeds up diabetic wound healing by mobilizing specific immune cells.
    The study investigated the effects of tibial cortex transverse transport (TTT) on wound healing in a type 2 diabetic rat model, using 186 male Sprague-Dawley rats. TTT-treated rats showed complete wound closure by day 21, faster than controls. Histological analysis indicated enhanced re-epithelialization, thicker epidermis, and organized collagen. Immunofluorescence revealed a shift from proinflammatory M1 to reparative M2 macrophages starting day 5. Flow cytometry indicated a surge of non-classical monocytes in bone marrow and blood. Depleting monocytes/macrophages delayed healing and disrupted collagen deposition. The study concludes that TTT accelerates diabetic wound healing through systemic mobilization of non-classical monocytes and increased M2 macrophage polarization, suggesting a mechanically induced immunomodulatory process.
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