Optimization of Ultrasound-Assisted Extraction of Bioactive Compounds from Carthamus Caeruleus L. Rhizome: Integrating Central Composite Design, Gaussian Process Regression, and Multi-Objective Grey Wolf Optimization Approaches

    October 2024 in “ Process Biochemistry ”
    Hamza Moussa, Farid Dahmoune, Sabrina Lekmine, Amal Mameri, Hichem Tahraoui, Sarah Hamid, Nourelimane Benzitoune, Nassim Moula, Jie Zhang, Abdeltif Amrane
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    TLDR Optimal conditions for extracting beneficial compounds from Carthamus caeruleus L. rhizomes were identified, improving efficiency.
    The study optimizes the ultrasound-assisted extraction of bioactive compounds, specifically total phenolic content (TPC) and total flavonoid content (TFC), from Carthamus caeruleus L. rhizomes using central composite design (CCD), Gaussian process regression (GPR), and multi-objective Grey Wolf optimization (GWO). Optimal extraction conditions were identified as 10% ethanol, 40°C, 20 minutes sonication, and a 50 mL/g solvent-to-solid ratio. GPR demonstrated superior predictive accuracy over CCD, and the study developed a user-friendly interface for predicting TPC and TFC, enhancing extraction efficiency. This approach provides a robust framework for optimizing bioactive compound extraction from medicinal plants.
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