TLDR Follicular mucinosis causes significant damage to hair follicle cells.
The study on the ultrastructure of follicular mucinosis, conducted by Akira Ishibashi and Tomotaka Chujo, used electron microscopy to examine affected hair follicles. It found a disappearance of cell organelles and granular agglutination of cytoplasmic matrices and nuclear chromatin, often linked with tonofilaments. Severe cytoplasmic degeneration was marked by myelin figures and onion-like aggregations of low-electron-density lamellar structures. Although granular substances and collagen fibrils coated with an amorphous material were observed, there was no evidence of mucin release through degeneration or degradation processes.
20 citations
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June 1964 in “Archives of Dermatology” Systemic corticosteroids may effectively treat follicular mucinosis.
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May 2008 in “Histochemistry and Cell Biology” Keratins are crucial for cell stability, wound healing, and cancer diagnosis.
31 citations
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August 2005 in “The American Journal of Dermatopathology” The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.
5 citations
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July 2019 in “Photodiagnosis and photodynamic therapy” Using tacalcitol ointment with photodynamic therapy may effectively treat follicular mucinosis with scalp hair loss.
51 citations
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May 1984 in “Journal of the American Academy of Dermatology” Benign follicular mucinosis involves immune cells attacking hair follicles.
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July 2013 in “Journal of Cutaneous Pathology” A woman's hair loss, resembling an autoimmune condition, improved after treatment, but requires ongoing checks due to potential serious associations.
