Uncertainty and Sensitivity Analysis of Hair Growth Duration in Human Scalp Follicles Under Normal and Alopecic Conditions

This study uses mathematical models to analyze hair growth cycles in human scalp follicles under normal, androgenetic alopecia (AGA), and alopecia areata (AA) conditions. It finds that AGA subjects have greater uncertainty in hair growth duration, while AA conditions show a more predictable, shorter growth phase. The sensitivity analysis reveals that in AGA, the synthesis of regulatory molecules in the dermal papilla and stem cell input significantly affect hair growth duration, consistent with androgen effects on hair follicles. The research, which relies on existing data and computational techniques, provides insights into the variability and sensitivity of hair growth dynamics, aiding the understanding of alopecia.