Upadacitinib Therapy in Adolescent Severe Alopecia Areata: A Case Series and Narrative Review

September 2025 in “ Clinical Cosmetic and Investigational Dermatology ”

Yimeng Gao, Chenyu Zhu, Hongzhong Jin

Upadacitinib Alopecia Areata severe Alopecia Areata

TLDR Upadacitinib is effective and safe for treating severe Alopecia Areata in adolescents.

The study highlights the effectiveness and safety of Upadacitinib as a treatment for adolescents suffering from severe Alopecia Areata (AA), specifically those without atopic comorbidities. This research adds valuable data to the existing knowledge on treating severe AA in this demographic, suggesting that Upadacitinib could be a viable therapeutic option.

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Research cited in this study

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research Efficacy of Upadacitinib in Treating Alopecia Areata, Atopic Dermatitis, and Th1 Comorbidities in Pediatric Patients: A Comprehensive Case Series and Literature Review

2 citations , May 2025 in “Journal of Clinical Medicine”

Upadacitinib is safe and effective for treating alopecia areata and atopic dermatitis in children.

$Treatment of Refractory Segmental Vitiligo and Alopecia Areata in a Child with Upadacitinib and NB-UVB: A Case Report$

research Treatment of Refractory Segmental Vitiligo and Alopecia Areata in a Child with Upadacitinib and NB-UVB: A Case Report

August 2024 in “Clinical Cosmetic and Investigational Dermatology”

Upadacitinib and narrowband UVB effectively treated a child's vitiligo and alopecia areata.

research Dupilumab Induces Hair Regrowth in Pediatric Alopecia Areata: A Real-World, Single-Center Observational Study

20 citations , July 2024 in “Archives of Dermatological Research”

Dupilumab helps children with alopecia areata regrow hair safely.

research Baricitinib for the Treatment of Alopecia Areata

6 citations , May 2023 in “Drugs”

Baricitinib helps regrow hair in adults with severe alopecia better than a placebo and is approved for treatment, but long-term effects are still unknown.

research Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata

9 citations , January 2023 in “Dermatology and therapy”

A 14-year-old girl with severe hair loss regrew her hair using upadacitinib.

research Upadacitinib for the Treatment of Alopecia Areata and Severe Atopic Dermatitis in a Pediatric Patient: A Case Report

7 citations , January 2022 in “SAGE open medical case reports”

Upadacitinib successfully treated a child's severe skin and hair loss issues.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

research Treatment of Pediatric Alopecia Areata: A Systematic Review

48 citations , April 2021 in “Journal of the American Academy of Dermatology”

Topical corticosteroids are the best initial treatment for children's alopecia areata.

Related Research

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.