UT-018 Accelerates Wound Repair And Hair Follicle Regeneration In Murine Models

May 2026 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Uday Saxena, Saranya K, Priyanka Jadhav, Shreya Shahapur, Sadiya Mehboob, Gopi Kadiyala, Markendeya Gorantla

UT-018 stem cell chemoattractant hair follicle regeneration wound repair collagen organization fibroblast activity blood vessel formation follicular density anagen phase cAMP β-catenin phosphorylation GPCR-mediated signaling

TLDR UT-018 speeds up wound healing and boosts hair growth in mice.

UT-018, a stem cell chemoattractant formulation, has shown significant regenerative effects in murine models for both wound healing and hair follicle regeneration. The topical application of UT-018 accelerated wound closure, improved granulation tissue formation, collagen organization, fibroblast proliferation, and dermal vascularization. In hair growth studies, UT-018 increased follicular density, enhanced follicular penetration, improved dermal vascularization, and induced anagen-phase transition. Mechanistic studies revealed that UT-018 promotes intracellular cAMP generation and β-catenin phosphorylation, indicating GPCR-mediated regenerative signaling.