Identification of Ultraviolet B Radiation-Induced MicroRNAs in Normal Human Dermal Papilla Cells

July 2014 in “ Molecular Medicine Reports ”

Hwa Jun, Ok‐Yeon Kim, Gang Tai Lee, Kwang-Sik Lee, Jae Ho Lee, In‐Chul Park, Su‐Jae Lee, Yu Ri Kim, Kyu Joong Ahn, In‐Sook An, Sungkwan An, Seunghee Bae

ultraviolet B radiation UVB normal human dermal papilla cells nHDPs cytotoxicity apoptosis reactive oxygen species ROS microRNAs miRNAs cell survival cell death

TLDR UVB radiation changes the levels of certain microRNAs in skin cells, which may affect cell survival and hair growth.

In the 2014 study, researchers found that UVB radiation at doses of ≥50 mJ/cm² caused significant cytotoxicity and apoptosis in normal human dermal papilla cells (nHDPs), which are crucial for hair follicle growth, as well as increased reactive oxygen species (ROS) generation. They identified 42 microRNAs (miRNAs) with significantly altered expression profiles after UVB exposure, with 35 being upregulated and 7 downregulated. These miRNAs are thought to be involved in cell survival and death-related functions, suggesting that miRNA-based cellular mechanisms may contribute to the UVB-induced cellular response in nHDPs.