Viewpoint 4

The document discussed the emerging understanding of adipose tissue as an endocrine organ, highlighting its role beyond energy storage and insulation. Research indicated that adipocytes express multiple hormone receptors and produce various hormones and mediators, termed adipokines, which influence metabolic processes and skin physiology. Leptin, a key adipokine, was shown to improve wound healing in mice, suggesting a local endocrine function in the skin. The document also explored the role of the CRH system in adipocytes, proposing its involvement in stress response and skin functions. Overall, the study emphasized the need to integrate adipose tissue into the understanding of the skin's endocrine functions and its communication with the brain.