Virilizing Adrenal Adenoma Co-Secreting Cortisol and DHEA-S: A Case Report

This case report describes a 43-year-old female with a virilizing adrenal adenoma co-secreting cortisol and DHEA-S, presenting with symptoms such as hirsutism, weight gain, and anxiety-depression. Initial tests showed elevated cortisol and DHEA-S levels, leading to a diagnosis of cyclic adrenal Cushing’s syndrome. A laparoscopic left adrenalectomy was performed, resulting in significant clinical improvement, including weight loss, reduced facial hair growth, and resolution of depression symptoms. Post-surgery tests confirmed the normalization of hormone levels, supporting the diagnosis of co-secretion by the adrenal adenoma. The case highlights the complexity of diagnosing adrenal disorders, especially in patients with a history of PCOS.