The Visitors of the Sick

Benign prostatic hyperplasia (BPH) was a common issue among older men, characterized by an enlarged prostate and urinary symptoms, potentially leading to complications like acute urinary retention (AUR) or surgery. Dihydrotestosterone played a key role in prostate growth, and 5alpha-reductase inhibitors (5ARIs) such as dutasteride and finasteride were used to treat BPH by inhibiting this hormone's production. These medications were effective in reducing prostate volume, improving urinary flow, alleviating symptoms, and decreasing the risk of AUR and surgery. 5ARIs were the only medical therapy available at the time that could prevent disease progression and provide long-term symptom control, making them essential for men with enlarged prostates at risk of progression.