Vitamin B3 (Niacin), B6, C, and Iron Intake Are Associated with the Free Androgen Index, Especially in Normoandrogenic Polycystic Ovary Syndrome

    Andon Brilliant, Brilliant Putri Kusuma Astuti, Ericko Ongko Joyo, Ririn Rahmala Febri, Vita Silvana, Raden Muharam
    TLDR Vitamins B3, B6, C, and iron intake affect hormone levels in women with certain types of PCOS.
    This study examined the relationship between micronutrient intake and androgen levels in 145 women, including 79 with polycystic ovary syndrome (PCOS) and 66 healthy controls. It found a significant negative correlation between the free androgen index (FAI) and intake of vitamins B1, B2, B6, niacin, calcium, and iron in the normoandrogenic (NA) PCOS group, but not in the hyperandrogenic (HA) group. Vitamin B6 intake negatively affected FAI, while vitamin C, niacin, and iron intake had a positive effect. These results suggested that micronutrients might influence PCOS pathology and androgen levels, particularly in NA PCOS. The study recommended further research with larger sample sizes and direct nutrient level measurements in plasma due to its limitations, including a small sample size and cross-sectional design.
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