Voltammetric Detection with a Comprehensive Electrochemistry Study of Minoxidil Using Nuclear Magnetic Resonance and Infrared Analyses: Applications in the Forensic and Pharmaceutical Fields

    November 2024 in “ Electrochimica Acta
    Anne A. Macedo, Dilton M. Pimentel, Amanda Neves de Souza, Higor M. Mundim, Luciano M. Lião, Lívia M.F. Costa, Rodrigo M. Verly, Wallans Torres Pio dos Santos
    TLDR A new, quick method accurately detects minoxidil in drugs and cosmetics.
    This study presents a comprehensive electrochemical analysis of minoxidil (MN) using a boron-doped diamond electrode (BDDE) combined with nuclear magnetic resonance (NMR) and Fourier transform infrared spectroscopy (FTIR). The research proposes a novel quasi-reversible redox mechanism for MN on the BDDE, which has not been previously reported. The study introduces a simple and rapid method for detecting and quantifying MN in pharmaceutical and forensic samples using square-wave cathodic stripping voltammetry (SWCSV) with an unmodified BDDE. This method is highlighted for its high selectivity and sensitivity, offering advantages over existing techniques for identifying MN in adulterated cosmetic and pharmaceutical products.
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