Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness

September 2023 in “ Animals ”

Wentao Zhang, Meilin Jin, Taotao Li, Zengkui Lu, Huihua Wang, Zehu Yuan, Caihong Wei

hair follicle development LGR4 PIK3CA NFIB OPHN1

TLDR Genes linked to wool fineness in sheep have been identified.

This study utilized whole-genome resequencing on 28 sheep to investigate the genetic basis of wool fineness, identifying 269 genes in fine wool sheep and 319 in coarse wool sheep. Researchers found 22,133,207 SNPs and used methods like Fst, θπ Ratio, and XP-EHH to identify candidate SNP loci and genes associated with wool fineness. Key genes such as LGR4, PIK3CA, NFIB, and OPHN1 were linked to hair follicle development. Enrichment analyses highlighted significant biological processes and pathways, providing valuable insights for future wool improvement efforts and breeding programs.

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