TLDR The Wnt signaling pathway is essential for skin repair and healing.
The document reviewed the role of the Wnt signaling pathway in epidermal repair, highlighting its importance in processes such as embryonic development, cancer treatments, and normal physiological functions in adults. It emphasized the pathway's critical role in epidermal stem cells, epidermal growth factors, and hair follicle development, which are essential for skin wound healing. The research on this pathway was considered to have significant clinical implications for understanding and enhancing skin tissue repair.
9 citations
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March 2019 in “Scientific reports” Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.
8 citations
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January 2017 in “Stem Cells International” A protein called sFRP4 from skin cells stops the development of pigment-producing cells in hair.
103 citations
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November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
260 citations
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June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
314 citations
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
137 citations
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September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
