The Role of WNT10B in Physiology and Disease: A 10-Year Update

    February 2023 in “ Frontiers in Cell and Developmental Biology ”
    Rachel S. Perkins, Rishika Singh, Amy N. Abell, Susan A. Krum, Gustavo A. Miranda‐Carboni
    TLDR WNT10B is important for body functions and linked to diseases like osteoporosis, obesity, and cancer.
    WNT10B is a crucial regulator in various physiological and pathological processes, including bone development, cancer, obesity, and hair growth. It activates the WNT/β-catenin signaling pathway, influencing cell differentiation and proliferation. In bone, it promotes osteoblast differentiation and bone mineral density while inhibiting adipocyte differentiation. WNT10B is also involved in immune regulation, influencing T-cell development, and has implications in conditions like periodontal disease and rheumatoid arthritis. It plays a significant role in hair follicle development and cycling, suggesting potential therapeutic applications for alopecia. In cancer, WNT10B acts as an oncogene in over 15 types, with its expression offering potential therapeutic targets. The document highlights the therapeutic potential of WNT10B in bone-related diseases, cancer, and hair growth, emphasizing the need for further research to explore its applications.
    Discuss this study in the Community →

    Research cited in this study

    13 / 13 results

    Related Community Posts Join

    3 / 3 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  50 upvotes 10 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 6 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Do you keep gains if you stop microneedling?

      in Microneedling  15 upvotes 5 months ago
      Stopping microneedling may result in losing hair gains, as it enhances the effectiveness of treatments like minoxidil. Combining microneedling with minoxidil and finasteride is more effective than using microneedling alone.

    Related Research

    1 / 1 results