Promising Improvement in Infected Wound Healing in Type 2 Diabetic Rats by Combined Effects of Conditioned Medium of Human Adipose-Derived Stem Cells Plus Photobiomodulation

November 2023 in “ Laboratory Animal Research ”

Kaysan Sohrabi, Houssein Ahmadi, Abdollah Amini, Behnaz Ahrabi, Atarodalsadat Mostafavinia, Hamidreza Omidi, Mansooreh Mirzaei, Fatemeh Fadaei Fathabady, Mohammadjavad Fridoni, Maryam Rahmannia, Sufan Chien, Mohammad Bayat

human adipose-derived stem cells conditioned medium photobiomodulation wound healing fibroblast blood vessel formation inflammation h-ASC-COM PBM

TLDR Combining stem cell medium and light therapy improves wound healing in diabetic rats.

The study examined the effects of combining human adipose-derived stem cell-conditioned medium (h-ASC-COM) and photobiomodulation (PBM) on wound healing in type 2 diabetic rats. The combination significantly improved wound healing outcomes, including wound closure, strength, and the presence of fibroblasts and new blood vessels, compared to either treatment alone. It also reduced inflammation and microbial presence. The study involved 24 Wistar rats and demonstrated that h-ASC-COM plus PBM was more effective than PBM or h-ASC-COM alone, suggesting this combined therapy could enhance diabetic wound healing. Further research is needed to optimize treatment protocols.

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