Zeb2 Recruits HDAC–NuRD to Inhibit Notch and Controls Schwann Cell Differentiation and Remyelination

    June 2016 in “ Nature Neuroscience ”
    Lai Man Natalie Wu, Jincheng Wang, Andrea Conidi, Chuntao Zhao, Haibo Wang, Zachary K. Ford, Liguo Zhang, Christiane Zweier, Brian Ayee, Patrice Maurel, An Zwijsen, Jonah R. Chan, Michael P. Jankowski, Danny Huylebroeck, Q. Richard Lu
    TLDR Zeb2 is crucial for nerve repair by controlling Schwann cell function.
    The study investigated the role of Zeb2 in Schwann cell differentiation and remyelination, revealing that Zeb2 recruited the HDAC–NuRD complex to inhibit Notch signaling, which was essential for Schwann cell differentiation and myelination in the peripheral nervous system. The findings underscored the significance of Zeb2 in regulating myelination processes and its interaction with the HDAC–NuRD complex in controlling the transcriptional program necessary for Schwann cell function and nerve repair, offering insights into the molecular mechanisms of peripheral nerve myelination and potential therapeutic targets for demyelinating diseases.
    Discuss this study in the Community →