ZNF750 Safeguards Upper Hair Follicle Homeostasis To Prevent Inflammatory Skin Disease

April 2026 in “ Journal of Investigative Dermatology ”

Uyanga Batzorig, Grace Zhang, Chang Yang, Ye Liu, Celia Fernández-Méndez, Samiksha Mahapatra, Jae‐Joong Kim, Neha Quadir, George L. Sen

ZNF750 zinc-finger transcription factor epidermal differentiation barrier formation lipid processing stratum corneum inflammatory skin diseases psoriasis seborrheic-like dermatitis psoriasiform phenotype skin barrier skin inflammation skin lipid processing

TLDR ZNF750 helps keep hair follicles healthy and prevents skin inflammation.

ZNF750 is a zinc-finger transcription factor crucial for maintaining upper hair follicle homeostasis by promoting epidermal differentiation and barrier formation in both murine and human skin. It activates genes responsible for lipid processing and stratum corneum development. Variations in ZNF750 are associated with inflammatory skin diseases, including psoriasis and seborrheic-like dermatitis with a psoriasiform phenotype.

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research Hair Follicles Modulate Skin Barrier Function

9 citations , June 2024 in “Cell Reports”

Hair follicles play a crucial role in regulating skin barrier function.