Novel Fabrication and Development of Multifunctional Zn/Fu@Cs Nanofibers Material for Wound Care and Operating Room Infection Control
October 2022
in “
Materials Research Express
”
zinc oxide fucoidan chitosan nanofiber scaffolds electrospinning antibacterial properties Pseudomonas aeruginosa Bacillus subtilis Staphylococcus aureus Escherichia coli cell proliferation cytocompatibility L929 cells wound scratch assay human skin fibroblast biodegradation biocompatibility ZnO P. aeruginosa B. subtilis S. aureus E. coli
TLDR The nanofibers effectively fight bacteria and help wounds heal faster.
The study focused on developing zinc oxide and fucoidan-loaded chitosan nanofiber scaffolds using the electrospinning method for wound care and infection control in operating rooms. The Zn/Fu@Cs nanofibers demonstrated significant antibacterial properties against P. aeruginosa, B. subtilis, S. aureus, and E. coli, and promoted cell proliferation and cytocompatibility in L929 cells within 3 days. The wound scratch assay on human skin fibroblast L929 cells showed quick cell regeneration without bacterial infections. The biodegradation study confirmed the biocompatibility of the nanofibers, suggesting their potential as a multifunctional material for wound care with enhanced antibacterial properties.
