10 citations
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March 2024 in “Endocrine Reviews” From 1965 to 2015, significant progress was made in understanding androgen excess disorders like premature adrenarche and polycystic ovary syndrome (PCOS). Key discoveries include the identification of unique plasma androgen patterns and the role of 11-oxytestosterones as major adrenal androgens. Research into PCOS pathogenesis highlighted areas such as neuroendocrinology, insulin resistance, and genetics, with genome-wide studies revealing the steroidogenic regulator DENND1A as a key factor. The DENND1A.V2 splice variant is overexpressed in PCOS theca cells, contributing to the PCOS phenotype. Obesity worsens PCOS symptoms through insulin resistance and increased testosterone production. Despite these advances, much remains to be understood about these disorders.
37 citations
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October 2006 in “Steroids” New sulfur-containing steroid analogs show promise for more targeted medical treatments.
41 citations
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March 2007 in “Steroids” New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.
139 citations
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December 2020 in “Cell Stem Cell” Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
159 citations
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July 2006 in “Endocrine Reviews” Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.