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research P.1.g.019 RY-023, an inverse agonist at alpha5 GABAA receptors: the influence on spatial memory and spontaneous locomotor activity

August 2008 in “European Neuropsychopharmacology”

RY-023, a specific drug, can improve early stage memory learning without affecting general activity in rats, but it's less effective for later learning stages and doesn't impact memory recall.

research P.1.g.018 Cognitive performance in adolescents with anorexia nervosa: subgroups in relation to neuropsychological impairment

August 2008 in “European Neuropsychopharmacology”

Some teenagers with anorexia nervosa have worse cognitive abilities, especially in visual and spatial tasks, and this is more common in those with a lower body weight.

research P18-14 Monitoring of cortisone and cortisol levels in hair during pregnancy

September 2024 in “Toxicology Letters”

Cortisone and cortisol levels in pregnant women’s hair increase as labor approaches, indicating higher stress.

research New case of trichorinophalangeal syndrome-like phenotype with a de novo t(2;8)(p16.1;q23.3) translocation which does not disrupt the TRPS1 gene

9 citations , May 2014 in “BMC medical genetics”

A woman with a unique syndrome similar to TRPS has a genetic change near the TRPS1 gene, affecting its regulation.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Vitexin Compound 1 may help reduce skin aging caused by UVA light.

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Community Join

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community How to use topical fin and user experiences with it

in General 104 upvotes 1 year ago

Topical finasteride and minoxidil, combined with microneedling, are recommended for treating thinning hair areas, with 1-2 sprays daily being effective and having fewer side effects than oral finasteride. Starting microneedling at 1.0mm is advised for effectiveness while minimizing invasiveness.

community Oral min/fin/dut, i saw a little progress in the initial 3 months, but after that nothing, it’s been 15 months now

in Journals / Progress Pictures 59 upvotes 1 year ago

The user has been using 2.5 mg oral minoxidil daily and initially 0.5 mg finasteride daily, later switching to 0.25 mg dutasteride daily, but has not seen significant progress in hair regrowth after 15 months. The user is concerned about crown balding and thinning despite treatment.

community On crucial details and pitfalls of formulating topical minoxidil

in Minoxidil 363 upvotes 5 months ago

Avoid home-compounding topical minoxidil due to potential risks and complications. Use proper equipment and techniques to prevent aerosolization and ensure effective dissolution.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community Why does this industry still revolve around 5-AR inhibitors?

in Research/Science 44 upvotes 5 years ago

Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stem cell therapy and RNA technology show promise but are not yet available.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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Clinics

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All 38 clinic results →