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community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 5 upvotes 2 years ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

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Research

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research Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits

January 2024 in “International journal of molecular sciences”

A brain-made hormone can protect against memory-related brain damage caused by harmful proteins.

research 17β-Estradiol Increases APE1/Ref-1 Secretion in Vascular Endothelial Cells and Ovariectomized Mice: Involvement of Calcium-Dependent Exosome Pathway

9 citations , August 2021 in “Biomedicines”

17β-estradiol boosts APE1/Ref-1 secretion in cells and mice via a calcium-dependent pathway.

research Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3α-androstanediol and 17β-estradiol

136 citations , January 2004 in “Neuroscience”

Testosterone increases seizure risk through its conversion to specific neurosteroids.

research Hormonal changes and hair growth during treatment of hirsutism with cimetidine.

2 citations , January 1984 in “PubMed”

Cimetidine does not significantly reduce hair growth in hirsutism.

research Serum AMH levels in the differential diagnosis of hyperandrogenemic conditions

9 citations , June 2014 in “European Journal of Obstetrics & Gynecology and Reproductive Biology”

Blood AMH levels are higher in women with PCOS than in those with other similar conditions.

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learn Ethynylestradiol

learn Ethinylestradiol

learn dehydroepiandrosterone

learn Estradiol

an estrogen promoting hair regrowth more commonly used in women

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