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11α-Hydroxyprogesterone, a Potent 11β-Hydroxysteroid Dehydrogenase Inhibitor, Is Metabolized by Steroid-5α-Reductase and Cytochrome P450 17α-Hydroxylase/17,20-Lyase to Produce C11α-Derivatives of 21-Deoxycortisol and 11-Hydroxyandrostenedione In Vitro

research 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro

7 citations , April 2019 in “The Journal of Steroid Biochemistry and Molecular Biology”

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

research Non-classical Congenital Adrenal Hyperplasia Presenting With Severe Androgenic Alopecia: A Case Report

February 2025 in “Cureus”

Early diagnosis and treatment of NCCAH can improve symptoms and fertility.

Non-Classic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Revisited: An Update with a Special Focus on Adolescent and Adult Women

research Non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency revisited: an update with a special focus on adolescent and adult women

117 citations , May 2017 in “Human Reproduction Update”

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Female Pattern Hair Loss in a Patient with 17α-Hydroxylase Deficiency

research Female Pattern Hair Loss in a Patient with 17?-hydroxylase Deficiency

4 citations , January 2010 in “Acta dermato-venereologica”

Low androgen levels can still cause female pattern hair loss.

research Serum AMH levels in the differential diagnosis of hyperandrogenemic conditions

9 citations , June 2014 in “European Journal of Obstetrics & Gynecology and Reproductive Biology”

Blood AMH levels are higher in women with PCOS than in those with other similar conditions.

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community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 2 years ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

community Anyone here who’s using Alfatradiol (17a-Estradiol) in consistency with some results?

in Treatment 8 upvotes 5 years ago

User discusses Alfatradiol (17a-Estradiol) as a potential hair loss treatment with mixed results. Concerns include low dosage, receptor theory, and possible increased aromatase activity on scalp.

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