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Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs

research Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs

15 citations , November 2015 in “Pharmacopsychiatry”

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors: Review Article for Pharmacists and Healthcare Professionals

research Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals

July 2025

5α-reductase inhibitors help treat prostate enlargement and hair loss but may cause side effects, requiring careful use.

research Pharmacological Role and Clinical Applications of 5α-Reductase Inhibitors-Review Article for Pharmacists and Healthcare Professionals

July 2025 in “Saudi Journal of Medicine and Public Health”

5α-reductase inhibitors effectively treat enlarged prostate and hair loss but require careful use due to possible side effects.

research MP09-17 METHYLATION OF SRD5A2 IN THE BLOOD AS A NOVEL BIOMARKER TO PREDICT SENSITIVITY TO 5-ARI TREATMENT

April 2024 in “The Journal of urology/The journal of urology”

SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.

The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana Tropicalis

research The Aromatase Inhibitor Fadrozole and the 5-Reductase Inhibitor Finasteride Affect Gonadal Differentiation and Gene Expression in the Frog Silurana tropicalis

37 citations , January 2009 in “Sexual Development”

Fadrozole and Finasteride change frog sex ratios and cause intersex animals with altered gene expressions.

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community 5ARi of choice not working yet? Paper Review for efficacy + safety

in Research/Science 14 upvotes 5 months ago

Dutasteride is more effective than finasteride for hair loss, especially at the crown and midscalp, but both have similar side-effect profiles with low incidence of sexual adverse events. Improvement is measured visually, and significant results may take over 12 months to appear.

community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community 5ar alpha reductase stimulation is different depending on whether it’s type 1 or 2

in Hair Systems 17 upvotes 3 years ago

The conversation discusses how different factors can stimulate type 1 and type 2 isoforms of 5-alpha reductase, which are enzymes linked to hair loss. Specific treatments mentioned include oral Dutasteride and topical Finasteride.

community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

22 upvotes 8 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

community Around 5 month update (24m) (min + fin)

in Progress Pictures 279 upvotes 7 months ago

A 24-year-old shared impressive hair regrowth results after 5 months using oral minoxidil (3mg) and finasteride (1mg) daily, along with weekly microneedling, without side effects. The user self-medicated through the Hims website and noticed significant changes by the third month.

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