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Sexual Dysfunction Related to Drugs: A Critical Review. Part V: Alpha-Blocker and 5-ARI Drugs

research Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs

15 citations , November 2015 in “Pharmacopsychiatry”

α-Blockers and 5-ARIs for BPH can cause sexual dysfunction, including erectile and ejaculatory issues.

research MP09-17 METHYLATION OF SRD5A2 IN THE BLOOD AS A NOVEL BIOMARKER TO PREDICT SENSITIVITY TO 5-ARI TREATMENT

April 2024 in “The Journal of urology/The journal of urology”

SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.

5α-Reductase Inhibitors and Male Reproduction

research 5α-Reductase Inhibitors (5ARIs) and Male Reproduction

15 citations , January 2017 in “Advances in Experimental Medicine and Biology”

5α-Reductase inhibitors can negatively affect male sexual function and, in some cases, significantly reduce sperm count, but these effects may be reversible.

research PCPT, MTOPS and the use of 5ARIs: a Canadian consensus regarding implications for clinical practice

13 citations , December 2012 in “Canadian Urological Association Journal”

5ARIs like finasteride can help prevent prostate cancer and treat BPH, but guidelines should be updated to reflect this.

research The Risk of Venous Thromboembolism (VTE) in Men with Benign Prostatic Hyperplasia Treated with 5-Alpha Reductase Inhibitors (5ARIs).

6 citations , August 2021 in “Clinical Epidemiology”

Men using 5-alpha reductase inhibitors for prostate issues may have a slightly higher risk of blood clots.

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community 5ARi of choice not working yet? Paper Review for efficacy + safety

in Research/Science 14 upvotes 6 months ago

Dutasteride is more effective than finasteride for hair loss, especially at the crown and midscalp, but both have similar side-effect profiles with low incidence of sexual adverse events. Improvement is measured visually, and significant results may take over 12 months to appear.

community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

24 upvotes 8 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 2 years ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community The case for 5ARI-free hair transplants: Dr. Zarev, Pittella, Sethi, Miln, and future treatments in development

in Treatment 13 upvotes 9 months ago

Some individuals experience side effects from 5AR inhibitors like finasteride and are considering hair transplants without these medications, with some opting for surgeons like Dr. Zarev. Others are exploring alternative treatments and waiting for new medications in development, while some discuss managing side effects through lifestyle changes or additional medications.

community Low dose spiro with 5ARI inhibitor

in Chat 2 upvotes 1 year ago

Spironolactone, finasteride, and dutasteride are discussed for hair maintenance, with concerns about testosterone and side effects like gynecomastia. Spironolactone is noted for use in both bodybuilding and hormone therapy, with low doses considered for minimizing side effects.

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