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Evaluation of New Pregnane Derivatives as 5α-Reductase Inhibitors

research Evaluation of New Pregnane Derivatives as 5.ALPHA.-Reductase Inhibitor.

23 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

New Progesterone Esters as 5α-Reductase Inhibitors

research New Progesterone Esters as 5.ALPHA.-Reductase Inhibitors.

22 citations , January 2001 in “Chemical & Pharmaceutical Bulletin”

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

17α-Acetoxy-6-Bromo-16β-Methylpregna-4,6-Diene-3,20-Dione: A New Steroidal Derivative with High Antiandrogenic Activity

research 17α-Acetoxy-6-bromo-16β-methylpregna-4,6-diene-3,20-dione

December 1998 in “Acta Crystallographica Section C-crystal Structure Communications”

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

research Altered Hormone and Bioactive Lipid Plasma Profile in Rodent Models of Polycystic Ovarian Syndrome Revealed by Targeted Mass Spectrometry

March 2025 in “Journal of Endocrinology and Metabolism”

Rodent models of PCOS show some hormone changes similar to humans, but also have key differences.

research A pilot study of ICG laser therapy of acne vulgaris: Photodynamic and photothermolysis treatment

108 citations , December 2003 in “Lasers in surgery and medicine”

ICG-enhanced NIR laser therapy may be a promising acne treatment with improvement and no side effects.

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Community Join

5 / 192 results

community Study of thousands of Fin users over 20 years finds no evidence of Fin induced sexual dysfunction

in Research/Science 370 upvotes 2 years ago

The conversation is about a finding that finasteride does not significantly increase the risk of sexual dysfunction, with users sharing mixed personal experiences regarding side effects.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 186 upvotes 1 year ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Finasteride does deplete important nuero-active steroids

in Research/Science 10 upvotes 3 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

in Finasteride/Dutasteride 191 upvotes 4 years ago

Finasteride can cause sexual side effects in less than 2% of men, but these often disappear over time, even if the treatment continues. Some users report persistent side effects, while others experience no issues or only temporary ones.

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