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research DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages

4 citations , August 2019 in “General and Comparative Endocrinology”

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Biosynthesis of Dihydrotestosterone by a Pathway That Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

research Biosynthesis of Dihydrotestosterone by a Pathway that Does Not Require Testosterone as an Intermediate in the SZ95 Sebaceous Gland Cell Line

36 citations , October 2009 in “Journal of Investigative Dermatology”

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

research Functional stem-cell based tissue engineered vascular grafts for high-risk donor populations

January 2015 in “D-Scholarship@Pitt (University of Pittsburgh)”

Diabetic patients' stem cells make vascular grafts more prone to clots, but new methods may improve grafts.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

DHT deficiency can disrupt cell connections in rat testes, possibly affecting fertility.

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community 5 month comparison after switching to dutasteride

in Progress Pictures 60 upvotes 3 years ago

The user's progress after using dutasteride for hair loss treatment, and how minoxidil is also a helpful part of this process which can take up to one year to see full effects.

community Finasteride affects both 5a reductase and 5b reductase

6 upvotes 6 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community UPDATE - 7 months 2,5 dutatesteride

in Update 9 upvotes 1 year ago

The user continues to experience hair loss despite using dutasteride 2.5mg, minoxidil 5mg, and ciclopirox shampoo, and plans to reassess after one year. Others report similar issues with dutasteride, with some switching to finasteride or adding RU58841.

community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

in Research/Science 26 upvotes 3 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 4 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

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