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research Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS)

March 2026 in “The Aging Male”

PDE5 inhibitors cause earlier adverse events in BPH treatment, requiring careful monitoring.

research Analysis of Data From Breast Diseases Treated With 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia

1 citations , April 2019 in “Clinical Breast Cancer”

Medicines for enlarged prostate may raise the risk of breast growth and tenderness but not breast cancer.

Risk of Erectile Dysfunction Associated with Use of 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia or Alopecia: Population-Based Studies Using the Clinical Practice Research Datalink

research Risk of erectile dysfunction associated with use of 5-α reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink

30 citations , September 2016 in “BMJ”

Taking 5-α reductase inhibitors for prostate enlargement or hair loss does not significantly raise the risk of erectile dysfunction.

research 5-Alpha-Reductase Inhibitors and Combination Therapy

15 citations , July 2016 in “Urologic Clinics of North America”

Finasteride and dutasteride are effective for long-term treatment of enlarged prostates but have sexual side effects and a risk of high-grade prostate cancer.

Trends in the Development of New Drugs for the Treatment of Benign Prostatic Hyperplasia

research Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia

14 citations , November 2006 in “Current Medicinal Chemistry”

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

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Community Join

5 / 194 results

community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

in Research/Science 26 upvotes 3 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 3 years ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community 3 months 5g Min only before/after, 26 y/o

in Is this regrowth? 451 upvotes 1 year ago

The user experienced significant hair regrowth after three months of using 5 mg oral minoxidil nightly and plans to add finasteride to maintain progress. Many recommend combining minoxidil with finasteride or dutasteride to prevent future hair loss.

community What Works to Restore Hairloss for Cis-Males? Not Much

in Treatment 20 upvotes 5 years ago

Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

community Hair follicles do die - my „hair“ is the proof of that statement.

in Female 9 upvotes 2 years ago

The user discusses their experience with hair loss despite taking estrogen and cyproterone, and estimates needing around 3000 grafts for a feminine hairline. They are considering getting the procedure done in Turkey due to high European costs.

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