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research Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors

1 citations , October 2020 in “Current Drug Discovery Technologies”

The research found that compound 6, a newly created steroid, is more effective at inhibiting 5α-reductase (an enzyme) than current treatments, suggesting it could be a better option for treating urinary tract symptoms in men.

research Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2

8 citations , June 2017 in “Steroids”

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

research The novel drug CS-891 inhibits 5alpha-reductase activity in freshly isolated dermal papilla of human hair follicles.

3 citations , December 2000 in “PubMed”

CS-891 may effectively treat hair loss by blocking enzymes in hair follicles.

research The medicinal activity of lyophilized aqueous seed extract of Lepidium sativum L. in an androgenic alopecia model

May 2023 in “Scientific Reports”

The seed extract of Lepidium sativum L. can potentially treat hair loss, showing effects similar to 5% minoxidil.

Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

research Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride

25 citations , September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

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community 5ar Type I in the frontal hair follicles - Dutasteride

in Finasteride/Dutasteride 21 upvotes 2 years ago

The conversation discusses that dutasteride may be more effective than finasteride for frontal hair loss due to higher 5ar Type 1 enzyme activity in that area. Some users question the validity of this information, while others confirm it with additional sources.

community Glycine supplementaion is said to strongly upregulate 5-alpha Reductase (5-ar) Activity

in Research/Science 13 upvotes 5 years ago

Glycine supplementation may increase 5-alpha reductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 3 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.

in Finasteride/Dutasteride 52 upvotes 3 years ago

Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.

community Do we know exactly why some people respond so great to dut/fin,min and others dont?

in Research/Science 29 upvotes 1 year ago

Genetic factors, enzyme activity, and DHT sensitivity affect individual responses to hair loss treatments like finasteride, minoxidil, and dutasteride. Starting treatments early can slow hair loss, but results vary among individuals.

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Insam Souidan
Phoenix, AZ, United States

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Insam Souidan