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research Decision letter: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

January 2017

MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.

research Endocrinology of Hirsutism: From Androgens to Androgen Excess Disorders

20 citations , January 2019 in “Frontiers of Hormone Research”

The book explains how excess male hormones can affect various conditions like Polycystic Ovary Syndrome and Cushing's disease.

research Dermatologic Changes in Experimental Model of Long COVID

1 citations , January 2024 in “Microorganisms”

Mice with a virus similar to COVID-19 had skin damage, but a special treatment helped repair it.

research Author response: Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

1 citations , March 2017

MFN2 mutations cause mitochondrial problems, leading to more upper body fat and lower leptin levels.

research Giant folliculosebaceous cystic hamartoma

January 2007 in “Linchuang pifuke zazhi”

A 15-year-old boy had a rare skin growth on his buttock.

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community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 94 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Adipose tissue layer and stem cells.

in Research/Science 4 upvotes 9 months ago

Adipose fat cells and stem cells may help treat hair loss by restoring the scalp's thickness. Treatments like NanoFat injections and Botox are discussed for their potential to promote hair growth.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 29 upvotes 1 year ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community The Big Fat Layer II

in Research/Science 26 upvotes 5 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

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