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GlossaryAdult Stem Cells

undifferentiated cells in adults that regenerate specific tissues

Adult stem cells, also known as somatic stem cells, are undifferentiated cells found throughout the body after development. They have the ability to self-renew and differentiate into various specialized cell types of the tissue or organ they reside in, playing a crucial role in tissue repair and regeneration. Unlike embryonic stem cells, adult stem cells are limited in their differentiation potential but are less likely to cause ethical concerns or immune rejection when used in therapies.

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research SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells

330 citations , December 2009 in “Cell stem cell”

SKPs are similar to adult skin stem cells and could help in skin repair and hair growth.

research Convergent Genesis of an Adult Neural Crest-Like Dermal Stem Cell from Distinct Developmental Origins

106 citations , September 2010 in “Stem cells”

Skin-derived precursors in hair follicles come from different origins but function similarly.

research SKPing a Hurdle: Sox2 and Adult Dermal Stem Cells

11 citations , December 2009 in “Cell stem cell”

Sox2-expressing cells can help grow hair and heal skin.

research Diversity of Adult Stem Cell Niches in the Dermal Compartment of Skin

1 citations , January 2018 in “Elsevier eBooks”

The skin's dermal layer contains true stem cells with diverse functions and interactions that need more research to fully understand.

research Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

37 citations , April 2017 in “npj Regenerative Medicine”

PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.

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community What do you guys think about Stem cell treatments

in Research/Science 5 upvotes 5 years ago

Stem cell and exosome injections for hair loss are discussed, with skepticism about their effectiveness and concerns about using non-genetically related stem cells. Dr. Deyarmin's treatments are mentioned, with some users questioning their legitimacy and others expressing curiosity.

community My Theory Of Androgenic Alopecia

in Research/Science 18 upvotes 8 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

in Research/Science 43 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

in Technology 111 upvotes 1 year ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community The Cure isn't 5 years away; it's already here.

in Research/Science 1005 upvotes 1 year ago

PP405 is a new topical treatment for hair loss, showing promise in trials but still requires finasteride for maintenance. There is skepticism about its effectiveness and safety, with concerns about needing finasteride to maintain results.

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