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GlossaryAerobic Glycolysis

process where glucose breaks down with oxygen to produce energy

Aerobic glycolysis, also known as oxidative glycolysis, is a metabolic process where glucose is broken down in the presence of oxygen to produce energy, carbon dioxide, and water. This process occurs in the mitochondria and is more efficient than anaerobic glycolysis, yielding up to 36-38 ATP molecules per glucose molecule compared to just 2 ATP in anaerobic conditions.

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research PIK3CA gain-of-function mutation in Schwann cells leads to severe neuropathy and aerobic glycolysis through a non-cell autonomous effect

June 2025 in “Proceedings of the National Academy of Sciences”

A PIK3CA mutation in Schwann cells causes severe nerve damage and increased glycolysis, but early treatment can help.

research 899 HIF1A stabilisation in the ORS of human hair follicles promotes aerobic glycolysis and synthesis of angiogenic factors

April 2019 in “Journal of Investigative Dermatology”

Stabilizing HIF1A in hair follicles may boost hair growth by enhancing energy production and blood vessel formation.

research Metabolism of Freshly Isolated Human Hair Follicles Capable of Hair Elongation: A Glutaminolytic, Aerobic Glycolytic Tissue

71 citations , June 1993 in “Journal of Investigative Dermatology”

research Human hair growth in vitro: a model for the study of hair follicle biology

133 citations , July 1994 in “Journal of Dermatological Science”

Human hair growth can be influenced by certain growth factors and has specific metabolic needs.

research Oxygen, Metabolism, and Regeneration: Lessons from Mice

35 citations , October 2017 in “Trends in Molecular Medicine”

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

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community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community Accelerated Hair Loss from Creatine

in Finasteride/Dutasteride 134 upvotes 9 months ago

Creatine may cause hair loss in some individuals, especially those on finasteride, despite no scientific link. Personal experiences suggest individual sensitivity to DHT could be a factor.

community Creatine is the opposite of minoxidil !

in Research/Science 321 upvotes 9 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Fats on your Head to Stop Hair Loss?

in Research/Science 141 upvotes 2 years ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

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