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AIRE-deficient rats developed severe autoimmune disease similar to APECED, useful for testing treatments.

AIRE deficiency causes hair loss similar to alopecia areata in mice.

Ruxolitinib may effectively treat APS-1 by reducing harmful immune responses.

Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.