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research Exogenous Alpha-Ketoglutaric Acid Alleviates Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway

4 citations , April 2025 in “Antioxidants”

Alpha-ketoglutarate protects rabbit skin cells from oxidative damage by activating a specific cell pathway.

research Effects of the Alpha-Ketoglutaric Acid on the Performance, Hair Follicle Development, and Antioxidant Capacity of Rex Rabbits

August 2025 in “Animal nutrition”

α-Ketoglutaric acid improves hair growth, rabbit performance, and antioxidant levels.

research Prospects of Alpha-Ketoglutaric Acid in the Treatment of Aging and Age-Related Diseases

June 2025

Alpha-ketoglutaric acid (AKG) is highlighted as a promising agent for treating aging and age-related diseases, with potential applications in dermatology and cosmetology. The analysis of scientific literature over the past 25 years indicates that AKG is involved in various cellular metabolic pathways, serving as an energy donor, precursor of amino acid biosynthesis, and epigenetic regulator. It plays roles in regulating immunity, oxidative stress, and preventing aging. Studies have demonstrated AKG's effectiveness in addressing age-related conditions such as osteoporosis, sarcopenia, neurodegenerative diseases, and metabolic disorders. Additionally, AKG may help reduce facial wrinkles and prevent hair loss, as evidenced by experiments on animals.

research The Effects of Oral 5-Alpha Reductase Inhibitors on Penile Intracavernosal Pressures and Penile Morphology in a Rat Model

2 citations , May 2019 in “PubMed”

Oral finasteride and dutasteride may negatively affect erectile function in rats.

research Male Androgenetic Alopecia

13 citations , June 2008 in “Springer eBooks”

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Community Join

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community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 13 upvotes 5 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

community Blood Test Results

in Update 6 upvotes 5 years ago

A 27-year-old male using Minoxidil, Finasteride, and dermarolling for hair loss shared blood test results and experienced side effects with Finasteride. Adjusting the Finasteride dosage helped reduce side effects.

community Self-Experiment - Topical Rapamycin or a-KB

in Treatment 4 upvotes 4 years ago

A user plans to create a DIY topical treatment for hair loss using Rapamycin, possibly combined with alpha-ketoglutaric acid (a-KG). They discuss the concentration and formulation process for Rapamycin, considering safety and skin penetration, and intend to apply it every other day to the scalp.

community I have a theory about hair loss

in Treatment 1 month ago

Hair loss is often linked to inflammation and DHT, with treatments like finasteride, dutasteride, and minoxidil being effective for many. Natural remedies like turmeric and oils are discussed, but medications are generally seen as more reliable for managing genetic hair loss.

community I’ve emailed MinoxidilMax and they’ve said they will try and make topical Procyanidin B2 within a month!

in Product 97 upvotes 4 years ago

User TH1RT33N_DR34M shares that MinoxidilMax plans to make topical Procyanidin B2 within a month. Users discuss the legitimacy of the product, quality control, and potential results from using it for hair loss.

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